Ingredients in descending order: synthetically derived urea powder, natural flavors, maltodextrin, citric acid, calcium silicate, sucralose.įrequently Asked Questions Q: Is ure-Na available wholesale for my pharmacy?Ī: ure-Na is currently available through McKesson, Cardinal, AmerisourceBergen and Morris & Dickson. If you are conducting a formulary review of ure-Na and would like a copy of the AMCP Dossier, please email us at or scroll down and click on the Contact Us button at the bottom of the page. This data has treatment lengths up to 270 days However, this isolated increase in not indicative of kidney function, and is similar to what may be seen when individuals consume a high protein diet with production of additional amounts of urea by the liver.īelow are three data sets that report pre and post treatment serum urea or BUN as well as serum or blood creatinine. Since the blood test for BUN measures Blood Urea Nitrogen levels, it is expected that when ure-Na is administered, an increase in BUN levels may be seen. As such, it is considered safe (GRAS designation by the FDA), and does not carry nephrotoxic or hepatotoxic potential. Ure-Na: BUN and Serum Creatinine Urea is produced normally in the body by the liver. Patients with hyponatremia associated with adrenal insufficiency Patients not appropriate for ure-Na Patients with hypovolemic hyponatremia Long term durability of urea treatment response Published data on the use of ure-Na in the inpatient setting More information can be found in the Buy ure-Na section of Ure-Na can also be ordered on this website or by calling 1-84. If a patient is discharged on a Friday, the next time most retail pharmacies will be able to get ure-Na will be Monday with their next wholesale delivery. We recommend that a patient be discharged on two or three days worth of ure-Na.
We recommend the prescription or order for ure-Na includes the NDC # or UPC # so it can be found in the pharmacy ordering system. Most retail pharmacies receive a daily shipment Monday - Friday from their pharmaceutical wholesalers where ure-Na is stocked. Ure-Na can be ordered from most retail pharmacies for next day arrival. NaCl 15g of urea found in 1 sachet of ure-Na equals 250 mOsm, equal to 14.7 500mg NaCl tablets or 7.35 1g NaCl tablets.ģ0g of urea found in 2 sachets of ure-Na equals 500 mOsm, equal to 29.4 500mg NaCl tablets or 14.7 1g NaCl tablets.ĭischarging or initiating a patient on ure-Na Urea also ameliorates hyponatremia in SIADH by a more specific effect, diminishing the natriuresis in association with increased medullary urea content.Įuropean Clinical Practice Guideline on the Diagnosis & Treatment of Hyponatremiaĭosing chart based off of the above European Guideline dose range
AMCP DOSSIER DEFINITION FREE
Urea normalizes serum sodium by inducing osmotic excretion of free water without associated electrolyte depletion. Mechanism of Action of urea for the treatment of hyponatremia Ure-Na is available in a box with 8 sachets containing 15g USP urea per sachet. Ure-Na is available for wholesale purchase from McKesson, Cardinal, ABC and Morris and Dickson.
AMCP DOSSIER DEFINITION CODE
Ure-Na code used in place of an NDC 62530-0000-11
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